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Elderly woman with subacute lower limb weakness and rapid systemic decline
  1. Charis Wong1,2,
  2. Adrian J Wills3,
  3. Neshika Samarasekera1,
  4. Donald Noble4,
  5. Colin Smith1,5,
  6. Richard Davenport1,6
  1. 1 Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
  2. 2 Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK
  3. 3 Department of Neurology, Queens Medical Centre, Nottingham, UK
  4. 4 Department of General Medicine, St John's Hospital, Livingston, UK
  5. 5 Department of Neuropathology, University of Edinburgh, Edinburgh, UK
  6. 6 Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
  1. Correspondence to Dr Charis Wong, Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK; charis.wong{at}


A 74-year-old woman developed bilateral leg weakness, with fluctuating cognitive and systemic symptoms that progressed despite treatment. Her diagnosis was confirmed at autopsy. Her case was discussed at the Edinburgh Clinical Neurology Course 2019 Clinicopathological Conference.

  • clinical neurology
  • neuropathology

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  • Presented at This case was presented at the 41st annual Edinburgh Clinical Neurology Course 2019.

  • Contributors CW took primary responsibility for writing this article and undertook a literature review. All authors contributed to the writing of this report. AJW provided critical appraisal of the case. CS provided pathological review and images.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed by Fiona McKevitt, Sheffield, UK.