A 67-year-old Brazilian man of African ancestry and his 60-year-old sister both presented with choreiform movements, although in the man these were significantly overshadowed by additional parkinsonism. The man also had a history of four epileptic seizures. Neurological examination in each also found slow saccades and a dysexecutive syndrome. Genetic tests for Huntington’s disease were negative but were positive for Huntington’s disease-like 2. There are various genetic causes of chorea diseases, and their correct identification is important for appropriate clinical management and genetic counselling.
- Alzheimer’s disease
- cerebellar ataxia
- movement disorders
- parkinson’s disease
- motor neuron disease
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Contributors 1. Case report project: A. Conception, B. Organization, C. Execution
2. Data collection: A. Case Report B. Genetic Analysis
3. Manuscript: A. Writing of the first draft, B. Review and Critique
ODS: 1A, 1B, 1C, 2A, 3A, 3B.
SDP: 1A, 1B, 1C, 2A, 3A.
ADO: 1A, 1B, 1C, 2A, 3A.
TPJ: 2A, 2B, 3B.
JWM: 2A, 2B, 3B.
VTC: 1A, 1B, 1C, 2A, 3A, 3B.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Consent obtained from parent(s)/guardian(s).
Provenance and peer review Not commissioned. Externally peer reviewed by Anne Rosser, Cardiff, UK, and Edward Wild, London, UK.
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