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Dysarthria and ptosis
  1. Rachael Matthews1,
  2. Farhat Mirza1,
  3. Rekha Siripurapu2,
  4. Ranjit Ramdass3,
  5. Anoop Ranjan Varma1,4,
  6. Rajiv Mohanraj1,4
  1. 1 Department of Neurology, Salford Royal Hospitals NHS Trust, Salford, UK
  2. 2 Department of Neuroradiology, Salford Royal Hospitals NHS Trust, Salford, UK
  3. 3 Department of Neurophysiology, Salford Royal Hospitals NHS Trust, Salford, UK
  4. 4 Division of Neuroscience and Experimental Psychology , The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK
  1. Correspondence to Rajiv Mohanraj, Department of Neurology, Salford Royal Hospitals NHS Trust, Salford M6 8HD, UK; Rajiv.Mohanraj{at}

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A 56-year-old man attended the emergency department with his wife, who reported that his speech had become slurred (he denied this) and that he may be having a stroke. The patient described only occasional swallowing difficulty. He had a 10-year history of progressive hearing loss requiring bilateral hearing aids. When aged 11 years, he had undergone resection and radiotherapy for a posterior fossa astrocytoma. He smoked cigarettes and took a statin for hyperlipidaemia.

On examination, he had dysarthria and bilateral ptosis. CT scan of head showed no acute changes. He was admitted for 3 days under the stroke team, and his symptoms improved. An MR scan of brain 5 days later showed the previous posterior fossa surgery with cerebellar atrophy, chronic small vessel disease but no acute infarction. He was referred to neurology.

In neurology outpatients, we obtained a 10-year history of worsening ptosis and vertical diplopia. In the preceding 12 months, there had been occasional slurred speech, swallowing difficulty, loss of balance and an abnormal sensation over the right upper lip. His symptoms would worsen towards the end of the day. His wife had noticed that his slurred speech had notably worsened on the evening he attended the emergency department. There was no limb weakness or sphincter problem. His hearing had progressively deteriorated over 10 years, for which he had attended an ENT clinic. Two MR scans of brain, 5 years apart had identified evidence of previous surgery, left cerebellar hemisphere atrophy, and enlargement of the fourth ventricle and cisterna magna.

On examination, he had bilateral hearing aids and a scar from a previous posterior fossa craniotomy. There was bilateral ptosis without fatigability. His eye movements were full but with vertical separation of images on right horizontal gaze. His speech was nasal in character. There was a spastic catch in the right arm, but …

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  • Twitter Rajiv Mohanraj @neuro_manc.

  • Contributors RMa and FM researched and wrote the manuscript. RS reported the MR scans and contributed to the manuscript. RR performed EMG studies and contributed to the manuscript. ARV was responsible for initial clinical care of the patient and contributed to the manuscript. RMo continues the care of the patient, contributed to the manuscript and had overall supervision of preparation and revision of the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Consent obtained directly from patient(s).

  • Ethics approval Not required, patient consent obtained.

  • Data availability statement No data are available.

  • Provenance and peer review Not commissioned. Externally peer reviewed by Richard Davenport, Edinburgh, UK.

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