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A 62-year-old man reported tingling and numbness in his hands over 8 months that had progressed to his wrists, and with hand weakness. Two years previously he had developed thickening of the skin on his face and blistering skin lesions on his hands. He also reported erectile dysfunction.
On examination, his facial skin was visibly thickened (figure 1). There was an ulcer overlying the second right proximal inter-phalangeal joint with the tendon exposed (figure 2) and multiple similar lesions on the hands. There was wasting of intrinsic hand muscles and extensor digitorum brevis. He had significant distal weakness in upper and lower limbs. Supinator and ankle reflexes were absent. Sensory examination showed absent pinprick and vibration sensation distally.
Contributors PJM contributed with conception and design of the manuscript, acquisition of data and review of the relevant literature. SMM contributed with the design of the manuscript, editing of the manuscript and review of the relevant literature. MDA, LC, JMM, AMT and RD contributed with the editing of the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; externally peer reviewed by Michael Lunn, London, UK.