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Anti-GFAP neuroinflammation with synchronous bilateral papillitis and characteristic imaging
  1. William John Utley1,
  2. Adam El-Dieb2,
  3. Andrew Martin Chancellor1
  1. 1 Neurology, Tauranga Hospital, Tauranga, New Zealand
  2. 2 Neuroradiology, Tauranga Hospital, Tauranga, New Zealand
  1. Correspondence to Dr William John Utley, Neurology, Tauranga Hospital, Tauranga 3134, New Zealand; will.j.utley{at}

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A 50-year-old female marine ecologist presented to the emergency department following 3 weeks of persistent headache, nausea, vomiting, disturbed vision, intermittent aural pulsations, unsteady gait and acroparesthesias. She had previously been healthy, specifically with no history of autoimmune disease.

Mental status, vital signs and general medical examination were normal. Corrected visual acuity 6/60 right; 6/9 left. There were bilateral scotomata extending from the point of fixation towards the temporal field, worse on the right. She had a right afferent pupillary light defect. Funduscopy showed bilateral disc swelling with obscuration of vessels within the disc margins, without haemorrhage. Gait was slightly ataxic. There were no other abnormalities of the cranial nerves, motor or sensory examination.

Haematology, chemistry and liver function tests were normal. Immunoglobulin (Ig)G 5.8 g/L (7.0–16.0) with IgA and IgM normal serum concentrations. Complement (C4) 0.18 g/L (0.2–0.6), with normal C3. Rheumatoid factor, anti-CCP IgG, antinuclear antibody, extractible nuclear antigen, anti-neutrophil cytoplasmic antibody (MPO+PR3), all normal. HIV and syphilis serology negative. Serum was negative for …

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  • Contributors WJU conceived and drafted the manuscript. AMC edited the manuscript. AE-D provided the imaging review and description.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed by Anu Jacob, Liverpool, UK, and Jackie Palace, Oxford, UK.

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  • Editors’ commentary
    Phil E M Smith Geraint N Fuller

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