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A difficult case
Grey matter abnormality in progressive multifocal leucoencephalopathy
  1. Christopher Yuki Itoh1,
  2. Han Sung Lee2,
  3. Alan Howe Yee1
  1. 1 Department of Neurology, University of California Davis School of Medicine, Sacramento, California, USA
  2. 2 Department of Pathology, University of California Davis School of Medicine, Sacramento, California, USA
  1. Correspondence to Christopher Yuki Itoh, Department of Neurology, University of California Davis School of Medicine, Sacramento, CA 95817, USA; citoh{at}ucdavis.edu

Abstract

Progressive multifocal leucoencephalopathy (PML) is a demyelinating white matter disease that most often affects immunocompromised people infected by JC virus. The diagnostic gold standard is demonstrable viral DNA or protein from histopathological tissue. However, there are few detailed descriptions of cortical grey matter involvement on neuroimaging. Here we describe the histopathological correlate of cerebral grey matter involvement and radiological accompaniment in a patient with biopsy proven PML.

  • infectious diseases
  • neuropathology
  • virology
  • neuroradiology
  • CSF

https://doi.org/10.1136/practneurol-2020-002852

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    Footnotes

    • Twitter @ItohChristopher

    • Collaborators Not applicable.

    • Contributors CYI and AHY drafted the original manuscript. CYI and AHY were directly involved in the patient’s care and management. All authors provided intellectual content for the manuscript and edited the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed by Nicholas Davies, London, UK.

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    • Editors’ commentary
      Highlights from this issue
      Geraint N Fuller Phil E M Smith
      Practical Neurology 2021; 21 183-183 Published Online First: 17 May 2021. doi: 10.1136/practneurol-2021-003071

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