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Neurological dilemma
Systemic lupus erythematosus presenting as Guillain-Barré syndrome
  1. Paul Christopher Kopanidis1,
  2. Alisa Kane2,
  3. Minh Anh Nguyen3,
  4. Romesh Markus1,4
  1. 1 Neurology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
  2. 2 Immunology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
  3. 3 Anatomical Pathology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
  4. 4 Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
  1. Correspondence to Dr Paul Christopher Kopanidis, Neurology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia; pkopanidis{at}live.com

Abstract

A 37-year-old woman developed progressive symmetrical weakness with areflexia, consistent with Guillain-Barré syndrome. After initially briefly responding to intravenous immunoglobulin, her weakness progressed markedly. Further investigation identified a new diagnosis of systemic lupus erythematosus with lupus nephritis. Following additional plasma exchange and corticosteroids, the lupus activity remitted and she made a complete neurological recovery.

  • neuropathy
  • peripheral neuropathology
  • neuroimmunology

https://doi.org/10.1136/practneurol-2020-002849

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    Footnotes

    • Contributors PCK performed the literature review and prepared the manuscript. AK provided critical review and editing. MAN provided histopathology imaging and annotations. RM provided critical review and editing.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned. Externally peer reviewed by Hugh Willison, Glasgow, UK.

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