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Contributors JYT: collected the clinical material and drafted/revised the manuscript. SKS: revision of the manuscript. YBIJ, UT: revision of the manuscript, study supervision.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed. Externally peer reviewed by Tom Hughes, Cardiff, UK.