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Myoedema with pseudohypertrophic hypothyroid myopathy (Hoffman’s syndrome)
  1. Aastha Takkar1,
  2. Julie Sachdeva1,
  3. Nikhil Vojjala2,
  4. Vivek Lal1
  1. 1 Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  2. 2 Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  1. Correspondence to Dr Aastha Takkar, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, Punjab, India; draastha49{at}


Myoedema is an under-recognised neurological sign that can help the bedside diagnosis of metabolic or endocrine myopathies. Myoedema together with pseudo-hypertrophy make a likely diagnosis of hypothyroid myopathy, and its identification may avoid unnecessary investigations.

  • myopathy
  • neuroendocrinology
  • muscular dystrophy

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  • Contributors AT: concept and design, acquisition of data and analysis and interpretation of data; manuscript preparation. JS: drafting the article, acquisition of data. NV: manuscript preparation. VL: drafting the article and revising the manuscript for critical analysis.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed by Jon Walters, Swansea, UK.

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