Article Text
Abstract
Cerebral radiation necrosis is the most serious late reaction to high doses of ionising radiation to the brain, and its treatment is generally unsatisfactory. We present a patient who developed cerebral radiation necrosis after protracted fluoroscopy during repeated embolisations of an extracranial arteriovenous malformation. Treatment with bevacizumab (a humanised murine monoclonal antibody against vascular endothelial growth factor) was followed by neurological and radiological improvements.
- cerebrovascular
- MR
- neuropathology
- radiotherapy
Statistics from Altmetric.com
Footnotes
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Disclaimer We used the CARE checklist when writing our report.
Competing interests LS is on advisory board for Takeda, MSD and Kyowa Kirin; received honoraria from Merck Darmstadt, MSD, Takeda and Kyowa Kirin; and has research agreements with Varian and ViewRay.
Provenance and peer review Not commissioned. Externally peer reviewed by Robin Grant, Edinburgh, UK, and Fiona McKevitt, Sheffield, UK.
Read the full text or download the PDF:
Other content recommended for you
- Successful treatment of quadriparesis from radiation myelopathy with bevacizumab in a patient with metastatic breast cancer
- Overview of the current concepts in the management of arteriovenous malformations of the brain
- Radiation-induced optic neuropathy: a review
- Proof-of-concept single-arm trial of bevacizumab therapy for brain arteriovenous malformation
- Radiation and the nervous system
- Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome
- Endovascular superselective treatment of brain tumors: a new endovascular era? A quick review
- Treatment of tongue telangiectasia in a patient with hereditary haemorrhagic telangiectasia
- Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD
- Double trouble: a tale of two radio-treatments