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Wall-eyed bilateral internuclear ophthalmoplegia associated with etanercept
  1. Tychicus Chen
  1. Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
  1. Correspondence to Tychicus Chen, Room 8219, 8th Floor, Gordon & Leslie Diamond Health Care Centre, 2775 Laurel St, Vancouver, BC V5Z 1M9, Canada; tychicus{at}

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A 46-year-old man presented with horizontal diplopia over 5 days. He had psoriatic arthritis that had been stable on etanercept for several years but he had interrupted treatment for 3 months for fear of immunosuppression during the coronavirus pandemic. He had restarted therapy 3 months before presentation after worsening arthritis. On examination, he had bilateral exotropia with impaired adduction and gaze-evoked abducting nystagmus bilaterally, as well as impaired upgaze with vertical gaze-evoked nystagmus (video 1). Pupillary responses, convergence and facial strength were spared. The remaining neurological examination was unremarkable. MR scan of the brain showed demyelination in the dorsal pons involving both medial longitudinal fasciculi (figure 1). He was treated with intravenous methylprednisolone 1 g/day for 3 days with rapid resolution of his eye movement abnormalities. Etanercept was stopped and his eye movements remained normal on follow-up 1 month later with no strabismus. Unfortunately, his psoriatic arthritis worsened, and methotrexate was started, although it was not as …

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  • Contributors The author confirms sole responsibility for the following: study conception and design, data collection, analysis and interpretation of the results, and manuscript preparation.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally reviewed by Luke Bennetto, Bristol, UK.

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