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Pineal gland as the source of the soul and third eye
  1. Costa Savva1,
  2. Martin R Turner2
  1. 1 Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  2. 2 Nuffield Department of Clinical Neurosciences, University of Oxford Medical Sciences Division, Oxford, UK
  1. Correspondence to Dr Costa Savva, Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UK; costa.savva{at}

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The pineal gland has been shrouded in mystery for millennia. To appreciate the complex sociocultural history of the pineal gland fully, we must go all the way back to the Greek physician and philosopher Galen (129–c.216). He studied it extensively, naming it after the nuts found in the cones of the stone pine. However, Galen’s understanding of the ventricular apparatus of the brain was limited. He was convinced that the ventricles contained not a fluid, but rather an airy or volatile substance that lent itself to the regulation of the ‘soul’, with the entrance to this metaphysical realm guarded by the pineal gland. These ideas persisted until the 16th century, when anatomist Vesalius (1514–1564) established categorically that no psychic phenomena flowed through the ventricles.

The 17th century ‘father of Western philosophy’ René Descartes (1596–1650) became especially enchanted with the pineal gland. He established, in his 1664 Treatise on Man, a theoretical construct for Man as containing both a physical body and also a non-physical or ‘immaterial’ mind. Influenced heavily by his staunch Christianity (which in turn incorporated dualist metaphysical frameworks from the works of Plato), Descartes was fascinated with the idea of the mind–body split and concluded that, while animals have a mechanistic body, they lack a ‘soul’. Descartes concluded that a God-given soul endows humans …

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  • Contributors CS drafted the manuscript. MRT conceived and edited the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned. Externally peer reviewed by Guy Leschziner, London, UK.

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  • Editors’ commentary
    Phil E M Smith Geraint N Fuller

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