Article Text
PDF
Abstract
A 73-year-old woman developed cognitive decline over 1 year. MR scan of the brain showed a focal asymmetrical leukoencephalopathy involving the right frontal, temporal, parietal and occipital lobes. Extensive laboratory investigations found no cause but brain biopsy identified amyloid-beta-related angiitis (ABRA), a potentially treatable cause of rapid-onset dementia. We gave intravenous methylprednisolone and then two courses of intravenous cyclophosphamide, after which her cognitive skills gradually but significantly improved over several months.
- dementia
Statistics from Altmetric.com
Footnotes
Contributors All authors contributed equally to the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned. Externally peer reviewed by Neil Scolding, Bristol, UK.
Linked Articles
- Editors’ commentary
- Editorial
Read the full text or download the PDF:
Other content recommended for you
- Creutzfeldt–Jacob disease mimics, or how to sort out the subacute encephalopathy patient
- Creutzfeldt–Jacob disease mimics, or how to sort out the subacute encephalopathy patient
- Cerebral amyloid angiopathy related inflammation: three case reports and a review
- Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon
- Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum
- CJD mimics and chameleons
- Amyloid-β transmission through cardiac surgery using cadaveric dura mater patch
- Relapsing cerebral amyloid angiopathy-related inflammation: the wax and the wane
- The diagnosis of primary central nervous system vasculitis
- Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis