Article Text

Download PDFPDF
Amyloid-beta-related angiitis: a treatable rapidly progressive dementia
  1. Memoona Nasir1,
  2. Donald Nortey1,
  3. Naveed Malek1,
  4. Fernanda Valerio2,
  5. Abhijit Chaudhuri1
  1. 1 Department of Neurology, Queen's Hospital, Romford, UK
  2. 2 Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK
  1. Correspondence to Dr Memoona Nasir, Department of Neurology, Queen's Hospital, Romford, UK; memoona.nasir{at}


A 73-year-old woman developed cognitive decline over 1 year. MR scan of the brain showed a focal asymmetrical leukoencephalopathy involving the right frontal, temporal, parietal and occipital lobes. Extensive laboratory investigations found no cause but brain biopsy identified amyloid-beta-related angiitis (ABRA), a potentially treatable cause of rapid-onset dementia. We gave intravenous methylprednisolone and then two courses of intravenous cyclophosphamide, after which her cognitive skills gradually but significantly improved over several months.

  • dementia

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors All authors contributed equally to the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned. Externally peer reviewed by Neil Scolding, Bristol, UK.

Linked Articles

  • Editors’ commentary
    Phil E M Smith Geraint N Fuller
  • Editorial
    N J Scolding

Other content recommended for you