Article Text
Abstract
Tumor-induced osteomalacia is a rare and often misdiagnosed condition that presents with progressively worsening unexplained chronic pain and proximal muscle weakness. The osteomalacia leads to multiple stress fractures which do not heal properly, leading to progressive disability. It is caused by chronic hypophosphatemia due to inappropriate urinary phosphate wasting. This is due to a typically benign mesenchymal tumor that over-secretes a phospaturic hormone. Neurologists need to appreciate the relevance of chronic hypophosphatemia in people with chronic unexplained pain, as timely diagnosis and treatment of tumour-induced osteomalacia can be curative.
- CLINICAL NEUROLOGY
- NEUROENDOCRINOLOGY
- METABOLIC DISEASE
- PAIN
Data availability statement
Data sharing not applicable as no datasets generated and/or analysed for this study.
Statistics from Altmetric.com
Data availability statement
Data sharing not applicable as no datasets generated and/or analysed for this study.
Footnotes
Contributors JTN contributed to the planning, conduct reporting and conception and design. JT contributed to the planning, conduct, acquisition of data, analysis and interpretation of data. MTC contributed to the planning, conduct, reporting, conception and design, analysis and interpretation of data MTD contributed to the planning, conduct, reporting, conception and design, acquisition of data, analysis and interpretation of data. IH contributed to the planning, conduct, reporting, conception and design, analysis and interpretation of data. JS contributed to the reporting, conception and design, acquisition and analysis of data. KD contributed to the planning, conduct, reporting, acquisition of data, analysis and interpretation of data. MT contributed to the reporting, analysis and interpretation of data.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned. Externally peer reviewed by Richard Davenport, Edinburgh, UK and Fiona McKevitt, Sheffield, UK.
Linked Articles
- Highlights from this issue
Read the full text or download the PDF:
Other content recommended for you
- Oncogenic osteomalacia due to phosphaturic mesenchymal tumour in the upper thoracic spine
- Metastatic prostate cancer presenting as tumour-induced osteomalacia
- Tumour-induced osteomalacia due to an intra-abdominal mesenchymal tumour
- A man with hypophosphataemia
- Challenging case of tumour-induced osteomalacia
- Successful treatment of tumour-induced osteomalacia after resection of an oral peripheral ossifying fibroma
- Hypophosphataemia-inducing mesenchymal tumour in the foot
- Tumour-induced osteomalacia due to residual benign glomangioma
- Investigating hypophosphataemia
- Disorders of phosphate metabolism