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Contributors JC identified the sign. JC and RM conceptualised the manuscript. JC and RM created the first draft. All authors contributed to the final version.
Funding JC is salary funded by the Guarantors of Brain under a Brain Entry Fellowship. The authors declare no other disclosures or funding relevant to this manuscript.
Competing interests None declared.
Provenance and peer review Not commissioned. Externally peer reviewed by Jon Walters, Swansea, UK and Tom Hughes, Cardiff, UK.