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A difficult case
Amantadine toxicity causing visual hallucinations
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  • Published on: 2 October 2023
    Amantadine is a N-metyhl-d-aspartate (NMDA) antagonist.
    • Bekir Burak Kılboz, Neurology Resident University of Health Sciences, Prof. Dr. Cemil Taşçıoğlu City Hospital, Istanbul, Turkey

    Amantadine is not a N-metyhl-d-aspartate (NMDA) receptor agonist as stated in the paper, as it's a NMDA antagonist.

    References:
    - Vanle B, Olcott W, Jimenez J, Bashmi L, Danovitch I, IsHak WW. NMDA antagonists for treating the non-motor symptoms in Parkinson's disease. Transl Psychiatry. 2018 Jun 15;8(1):117. doi: 10.1038/s41398-018-0162-2. PMID: 29907742; PMCID: PMC6003962.,
    - Kornhuber J, Weller M, Schoppmeyer K, Riederer P. Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm Suppl. 1994;43:91-104. PMID: 7884411.

    Note from the editors:
    an erratum will be published

    Conflict of Interest:
    None declared.