Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
To sleep, perchance to dream
Our nearest shared ancestor with the octopus lived 550 million years ago and their brain evolution is therefore independent of ours. Quiet sleep in octopuses is rhythmically interrupted by 60 second long bouts of pronounced body movements and rapid changes in skin patterning and texture. Sleep staging in the octopus is possible by looking at these skin patterns and 'active sleep' resembles the awake patterns. Studying local field potential activity again says that these ‘active sleep’ periods resemble waking and are strongest in superior frontal and vertical lobe, which are connected and have a role in learning and memory function.
Migraine treatment is at risk of getting seriously interesting, seriously quickly. It has been quite some time since AFB was taken out for dinner by the ‘Go have a lie down in a dark room’ medical reps who were pushing their wares. Overlooking the hubris of calling an RCT ‘Progress’ (this looks good when the trial is positive, not so much when it stalls), they studied the utility of atogepant an oral calcitonin gene-related peptide receptor antagonist. A total of 778 people were randomised to placebo, versus drug once a day, versus drug twice a day—and a mean monthly migraine days reduction was the primary end-point. All three groups improved (likely return to the mean) but treatment was better than placebo (and 30 mg twice a day fared better than the 60 mg once daily). Constipation seen in 10% was the most common side effect, followed by weight loss (6%).
Lancet 2023;S0140-6736: 01049–8.
Diet of worms
AFB sometimes stretches for the best header for each Carphology piece, so hats off to the Guardian who lead with ‘Oh my God’ when describing the removal of a live 8 cm roundworm from the brain of an Aussie with ‘forgetfulness’. This type of roundworm had never caused CNS disease and it took an experienced parasitologist in Canberra to identify it, normally seen in pythons (figure 1). Although she had no direct contact with snakes, the 64-year-old patient lived adjacent to an area where carpet pythons live—which sounds very much out of the frying pan and in to the fire from a UK perspective. But a casual ‘business as usual’ or ‘no worries!’ to a typical Aussie.
Data availability statement
Data are available on reasonable request.
Patient consent for publication
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.