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Contributors ZX drafted the manuscript, obtained medical history and materials; KJ designed and conceptualised study; CY and YZ revised the manuscript for intellectual content.
Funding This work was supported by the National Key R&D Programme of China (No.2021YFC2700904), National Natural Science Foundation of China (No.82171394), Qingdao Technology Programme for Health and Welfare (22-8-7-smjk-1-nsh) and the Taishan Scholars Programme of Shandong Province, General Project on Educational and Teaching Reform Research of Shandong University(2023Y026), Undergraduate Education Teaching Research and Reform Project of Cheeloo College of Medicine of Shandong University(qlyxjy-202319).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed by Tom Hughes, Cardiff, UK.
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