Magnetic resonance direct thrombus imaging (MRDTI) is the first technique that directly visualizes thrombus in humans in vivo. Thrombus is associated with a substantial reduction in T1 caused by the paramagnetic properties of methaemoglobin, and this produces high signal intensity (bright) on T1-weighted images against a background of suppressed blood and fat (dark). This displays a positive image of thrombus without having to use intravenous contrast. Furthermore, direct visualization of thrombus rather than its indirect detection as a filling defect in flowing blood, or by surrogate markers such as changes in venous flow dynamics, overcomes many of the pitfalls of conventional imaging techniques and should provide an immediate definitive answer as to the presence or absence of clot. Moreover, simultaneous imaging of the legs and chest allows a comprehensive ascertainment of thrombus load.
Preliminary studies have shown that MRDTI is highly accurate for the diagnosis of both deep venous thrombosis
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Other content recommended for you
- Pulmonary embolism: update on management and controversies
- Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis
- Venous thromboembolism in patients with cancer: design and rationale of a multicentre, prospective registry (Cancer-VTE Registry)
- Risk of venous thromboembolism in patients undergoing gastric cancer surgery: protocol for a systematic review and meta-analysis
- Venous thromboembolism
- Risk of post-discharge venous thromboembolism in patients with rheumatoid arthritis undergoing knee or hip arthroplasty. Is prolonged thromboprophylaxis warranted or dangerous?
- Antithrombotic therapy for prophylaxis and treatment of venous thromboembolism in patients with cancer: review of the literature on current practice and emerging options
- Prevention of venous thromboembolism in ambulatory patients with cancer
- Incidence and risk factors for development of venous thromboembolism in Indian patients undergoing major orthopaedic surgery: results of a prospective study
- Clot regression effects of rivaroxaban in the treatment of venous thromboembolism in patients with cancer (CRERIT-VTE cancer): study protocol