Parry-Romberg syndrome, which is also called progressive facial hemiatrophy, overlaps with a condition known as linear scleroderma “en coup de sabre”. It is a rare, acquired, neurocutaneous syndrome of unknown aetiology. The principle features are atrophy of the soft tissues, and sometimes the bone, on one half of the face or forehead without facial weakness. Sometimes the atrophy extends to the limbs, usually on the same side, and there may be various ophthalmological and neurological complications. As a neurologist you should know about this syndrome because you will probably encounter at least one or two cases during your career, perhaps to assess new onset facial asymmetry, hemi-masticatory spasm, or because a patient already with the diagnosis has developed epilepsy or difficult migraine. Patients with Parry-Romberg syndrome present to various other clinics—especially dermatology, plastic surgery, and rheumatology.