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Parkinson’s disease: trials and travesties
  1. Paul Morrish, Consultant Neurologist
  1. Gloucestershire Hospitals NHSFoundation Trust, Great Western Road, Gloucester GL1 3NN, UK;

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    In the February issue, Dr Playfer highlighted ageism in Parkinson’s disease (PD) trials.1 This is only one reason why neurologists with an interest in PD might look back with embarrassment. He describes the CALM-PD, RQP 056 and CBS 09 studies as excellent, yet they all failed to answer the basic clinical question for even the recruited populations: with which drug should we start treatment for PD, an agonist, L-dopa or an MAOB inhibitor? The trials showed that agonists caused fewer …

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