In this issue we are starting a new series called “What to do ...”. Like all really good ideas I have taken up in my life, this one didn’t come from me—I think it was from an Editorial Board meeting. We all need to know what to do when the going gets tough, in this context of being a practical neurologist. You could go to a large textbook, but those monster door stops do not usually have a section like this among the traditional headings of “epidemiology”, “pathology”, “clinical features”, “differential diagnosis”, “investigations”, “prognosis” and “management”. PubMed …