Coeliac disease is a chronic immune-mediated disorder that primarily affects the gastrointestinal tract. There is an inflammatory response in the intestine to the ingestion of gluten which improves with a gluten-free diet. Many patients, especially adults, may be asymptomatic or have only extraintestinal symptoms at onset without any of the classical coeliac symptoms. In the last two decades there have been increasing numbers of reports describing neurological complications of coeliac disease, especially ataxia, peripheral neuropathy and epilepsy. This literature has become quite controversial, with disputes over the definition of coeliac disease and gluten sensitivity, whether neurological complications are caused by coeliac disease or are epiphenomena, and whether the proposed complications respond to a gluten-free diet. This review uses an evidence-based approach to critically assess this literature and provides guidelines for the evaluation and management of these patients.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Read the full text or download the PDF:
Other content recommended for you
- Neurological complications of coeliac disease
- Neuropathy associated with gluten sensitivity
- Gluten sensitivity masquerading as systemic lupus erythematosus
- Hippocampal sclerosis in refractory temporal lobe epilepsy is associated with gluten sensitivity
- Celiac disease and non-celiac gluten sensitivity
- IgG1 antiendomysium and IgG antitissue transglutaminase (anti-tTG) antibodies in coeliac patients with selective IgA deficiency
- Gluten sensitivity as a neurological illness
- Coeliac disease in Williams syndrome
- A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency
- Autonomic neuropathy and coeliac disease