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Brain histology
  1. A Jeans,
  2. M Esiri
  1. Specialist Registrar in Neuropathology, Oxford Radcliffe NHS Trust, Oxford, UK
  2. Consultant Neuropathologist, Oxford Radcliffe NHS Trust and Emeritus Professor, Department of Clinical Neurology, University of Oxford, Oxford, UK
  1. Professor M Esiri, Oxford Radcliffe NHS Trust; Emeritus Professor, Neuropathology Department, Level 1, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK; Margaret.esiri{at}


In this article we summarise nervous system histology in health and disease and acquaint the reader with developments in the staining techniques that are in current use, particularly immunostains. Although clinicians do not need to know the details of stain appearances, some familiarity with these aspects of neuropathology is invaluable in interpreting the reports they receive from the laboratory, as well as reminding them of the amazing beauty of the central nervous system’s microscopic structure.

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