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Recommendations on diagnosis and treatment of depression in patients with multiple sclerosis
  1. Yara Dadalti Fragoso1,
  2. Tarso Adoni2,
  3. Andrea Anacleto1,
  4. Paulo Diniz da Gama3,
  5. Marcus Vinicus Magno Goncalves4,
  6. Andre Palma da Cunha Matta5,
  7. Monica Fiuza Koncke Parolin6
  1. 1Department of Neurology, MS Reference Center, Universidade Metropolitana de Santos, Santos, SP, Brazil
  2. 2Department of Neurology, MS Reference Center, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil
  3. 3Department of Neurology, MS Reference Center, Pontificia Universidade Catolica de Sao Paulo, Campus Sorocaba, Sorocaba, SP, Brazil
  4. 4Department of Neurology, MS Unit, Centro Hospitalar Unimed, Joinville, SC, Brazil
  5. 5Department of Neurology, MS Reference Center, Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Niterói, RJ, Brazil
  6. 6MS Reference Unit Curitiba, Neurology Clinic, Curitiba, PR, Brazil
  1. Correspondence to Professor Yara Dadalti Fragoso, Department of Neurology, MS Reference Center, Universidade Metropolitana de Santos, Rua da Constituicao 374, Santos, SP CEP 11015-470, Brazil; yara{at}


Multiple sclerosis (MS) is frequently associated with depression. Yet there are few clinical trials on treating depression in MS and no agreed recommendations for its assessment and follow-up. We present evidence-based recommendations for several aspects of depression in MS, including screening for depression, recognition of other concomitant psychiatric conditions, suicide risk, disability, fatigue, cognition, adherence to treatment, the effect of drugs used to treat MS on depression and possible pharmacological treatments for depression in MS.

  • Depression
  • Multiple Sclerosis
  • Neuroimmunology

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