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Hypothyroid ataxia complicating monoclonal antibody therapy


We present a case of cerebellar dysfunction due to severe hypothyroidism induced by pembrolizumab, a member of the ‘immune checkpoint inhibitor’ class of cancer immunotherapies. Thyroxine replacement completely resolved his symptoms and signs. We also discuss the neurological immune-related complications of checkpoint inhibitors.

  • neuroimmunology
  • cerebellar ataxia
  • neuroendocrinology

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