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Focal precentral gyrus involvement in osmotic demyelination
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The case
A previously well 59-year-old woman was admitted to a regional hospital with subacute encephalopathy and found to have severe hyponatraemia (101 mmol/L). She had taken indapamide for hypertension over the preceding 3 months. Before referral to neurological services, she had received intravenous hypertonic saline. Her serum sodium concentration normalised within a few days, but was associated with a deteriorating conscious level. She was referred to our tertiary neurological centre with suspected osmotic demyelination where she presented in a ‘locked in’ state, involving quadriplegia and absent vertical …
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