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Focal precentral gyrus involvement in osmotic demyelination
  1. Martin R Turner1,
  2. John Jacob1,2,
  3. Lucy Matthews3,
  4. Fintan Sheerin3
  1. 1 Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford, UK
  2. 2 Department of Neurology, Milton Keynes University Hospital, Milton Keynes, UK
  3. 3 Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK
  1. Correspondence to Professor Martin R Turner, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University, OX3 9DU, Oxford, UK; martin.turner{at}ndcn.ox.ac.uk

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The case

A previously well 59-year-old woman was admitted to a regional hospital with subacute encephalopathy and found to have severe hyponatraemia (101 mmol/L). She had taken indapamide for hypertension over the preceding 3 months. Before referral to neurological services, she had received intravenous hypertonic saline. Her serum sodium concentration normalised within a few days, but was associated with a deteriorating conscious level. She was referred to our tertiary neurological centre with suspected osmotic demyelination where she presented in a ‘locked in’ state, involving quadriplegia and absent vertical …

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