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Clinicopathological case: progressive somnolence and dementia in an accountant: when the shine rubs off the gold standard
  1. Tim Soane1,
  2. Jonathan M Schott2,
  3. Jon Stone1,
  4. Colin Smith3,
  5. Richard J Davenport1
  1. 1Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
  2. 2Dementia Research Centre, University College London Institute of Neurology, London, UK
  3. 3Department of Neuropathology, Western General Hospital, Edinburgh, UK
  1. Correspondence to Dr Tim Soane, Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK; tsoane{at}


A 63-year-old accountant developed progressive somnolence, cognitive decline, gait disturbance and cerebellar dysfunction with autonomic features. This report documents the clinicopathological conference at the 39th Edinburgh Advanced Neurology Course 2017.

  • paraneoplastic
  • dementia
  • IgLON5
  • clinicopathological conference

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  • Contributors TS: initial draft, subsequent revisions. JMS: CPC discussant, manuscript revisions. JS: manuscript revisions. CS: CPC pathologist, manuscript revisions. RJD: overall conception, manuscript revisions.

  • Competing interests None declared.

  • Patient consent Next of kin consent obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed by Seth Love, Bristol, UK, and Jeremy Brown, Cambridge, UK.

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