Footnotes

• Collaborators Genomics England Research Consortium contributors: J C Ambrose, P Arumugam, E L Baple, M Bleda, F Boardman-Pretty, J M Boissiere, C R Boustred, H Brittain, M J Caulfield, G C Chan, C E H Craig, L C Daugherty, A de Burca, A Devereau, G Elgar, R E Foulger, T Fowler, P Furió-Tarí, J M Hackett, D Halai, A Hamblin, S Henderson, J E Holman, T J P Hubbard, K Ibáñez, R Jackson, L J Jones, D Kasperaviciute, M Kayikci, L Lahnstein, K Lawson, S E A Leigh, I U S Leong, F J Lopez, F Maleady-Crowe, J Mason, E M McDonagh, L Moutsianas, M Mueller, N Murugaesu, A C Need, C A Odhams, C Patch, D Perez-Gil, D Polychronopoulos, J Pullinger, T Rahim, A Rendon, P Riesgo-Ferreiro, T Rogers, M Ryten, K Savage, K Sawant, R H Scott, A Siddiq, A Sieghart, D Smedley, K R Smith, A Sosinsky, W Spooner, H E Stevens, A Stuckey, R Sultana, E R A Thomas, S R Thompson, C Tregidgo, A Tucci, E Walsh, S A Watters, M J Welland, E Williams, K Witkowska, S M Wood, M Zarowiecki.

• Contributors KS: drafting of the report; HMC: genetic analysis; Genomics England Research Consortium: generation of genomic data; SB, FR-G and SMS: critical review of the report.

• Funding KS is supported by a Wellcome Trust Strategic Award (WT104033AIA). HMC, SB and SMS are supported by the Epilepsy Society. SB is supported by the Muir Maxwell Trust. Part of this work was undertaken at University College London Hospitals, which received a proportion of funding from the NIHR Biomedical Research Centres funding scheme. The 100,000 Genomes Project is funded by the National Institute for Health Research and NHS England. The Wellcome Trust, Cancer Research UK and the Medical Research Council have also funded research infrastructure. The 100,000 Genomes Project uses data provided by patients and collected by the National Health Service as part of their care and support.

• Competing interests SMS reports representing the Association of British Neurologists and The Royal College of Physicians (London) at the MHRA Valproate Stakeholders Network, is a member of the scientific advisory board of Dravet Syndrome UK, patron of AHC UK, and has received honoraria or grant funding from UCB, Eisai, Vitaflo and Nutricia. SB has received honoraria from UCB. KS and HMC declare no potential competing interests. FR-G is a committee member of the MHRA Neurology, Pain and Psychiatry Expert Advisory Group and MHRA Sodium Valproate Expert Working Group, and council member of ILAE British branch and has received honoraria from LivaNova.

• Patient consent for publication Not required.

• Ethics approval The study was approved by the National Research Ethics Service Committee London—Camden and Islington (11/LO/2016).

• Provenance and peer review Not commissioned. Externally peer reviewed by Rhys Thomas, Newcastle-upon-Tyne, UK, and Mark Manford, Cambridge, UK.

• Data availability statement Data are available to bona fide researchers upon reasonable request and subject to data protection, ethics approval and Genome England requirements.