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Neurological dilemma
Systemic lupus erythematosus presenting as Guillain-Barré syndrome
  1. Paul Christopher Kopanidis1,
  2. Alisa Kane2,
  3. Minh Anh Nguyen3,
  4. Romesh Markus1,4
  1. 1Neurology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
  2. 2Immunology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
  3. 3Anatomical Pathology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
  4. 4Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
  1. Correspondence to Dr Paul Christopher Kopanidis, Neurology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia; pkopanidis{at}live.com

Abstract

A 37-year-old woman developed progressive symmetrical weakness with areflexia, consistent with Guillain-Barré syndrome. After initially briefly responding to intravenous immunoglobulin, her weakness progressed markedly. Further investigation identified a new diagnosis of systemic lupus erythematosus with lupus nephritis. Following additional plasma exchange and corticosteroids, the lupus activity remitted and she made a complete neurological recovery.

  • neuropathy
  • peripheral neuropathology
  • neuroimmunology

https://doi.org/10.1136/practneurol-2020-002849

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    Footnotes

    • Contributors PCK performed the literature review and prepared the manuscript. AK provided critical review and editing. MAN provided histopathology imaging and annotations. RM provided critical review and editing.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned. Externally peer reviewed by Hugh Willison, Glasgow, UK.

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