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Paraneoplastic opsoclonus-myoclonus-ataxia syndrome secondary to ovarian cancer
  1. Andrew W McHattie,
  2. Diana Wei,
  3. Hena Ahmad,
  4. Niran Nirmalananthan
  1. Department of Neurology, Atkinson Morley Neurosciences Centre, St George’s Hospital, Blackshaw Road, Tooting, London, UK
  1. Correspondence to Dr Andrew W McHattie, Neurology, St George's Hospital Atkinson Morley Regional Neuroscience Centre, London SW17 0QT, UK; AndrewWilliam.mchattie{at}

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Case presentation

A 63-year-old woman presented as a thrombolysis call with dysarthria, diplopia, vertigo and generalised weakness. She had a history of high-grade serous ovarian cancer, treated 3 years previously with surgery and chemotherapy and believed to be in remission. She also had osteoarthritis of the hips. On examination, there was mild dysarthria, abnormal eye movements in horizontal and vertical planes and generalised limb weakness. MR scan of brain without contrast was normal. The initial diagnosis on the stroke unit was of benign paroxysmal positional vertigo with lower limb weakness exacerbated by hip pain, and probable functional overlay. An Epley manoeuvre gave only minimal clinical benefit. The neurology team assessed her and noted several weeks of progressively slurred speech, oscillopsia, reduced upper limb coordination and unsteady gait. On examination, she had cerebellar dysarthria with frank …

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  • Contributors AWM is the first author. All other authors contributed equally.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally reviewed by Mark Lawden, Leicester, UK and Neil Anderson, Auckland, New Zealand.

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