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Toluene-induced leukodystrophy from glue sniffing
  1. Yue Hui Lau1,
  2. Ahmad Shahir Mawardi1,
  3. Norzaini Rose Zain2,
  4. Shanthi Viswanathan1
  1. 1Neurology Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
  2. 2Radiology Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
  1. Correspondence to Dr Yue Hui Lau, Neurology, Hospital Kuala Lumpur, Kuala Lumpur 50586, Malaysia; andrealau38{at}gmail.com

Abstract

A 33-year-old man with a history of chronic toluene abuse through glue sniffing, developed tremors, cerebellar signs and cognitive decline. MR scan of the brain showed global cerebral and cerebellar atrophy with symmetrical T2-weighted hypointensities in the basal ganglia, thalami and midbrain. After stopping glue sniffing, his tremors, ataxia of gait, speech and cognition partially improved. Early recognition and intervention of toluene-induced leukodystrophy could prevent ongoing morbidity and premature mortality.

  • toluene
  • bagging
  • leukodystrophy
  • cerebral atrophy
  • encephalopathy

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Footnotes

  • Twitter @andrealau38

  • Contributors Concept study and discussion: SV, YHL and ASM. Design and literature: YHL and SV. Data, statistical analysis and overview: all authors. Collection: YHL and NRZ.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed. Externally peer reviewed by Robin Howard, London, UK.

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