Article Text
Abstract
Chronic immune sensory polyradiculopathy (CISP) is a rare variant of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We describe a man with isolated sensory ataxia whose initial investigations included normal nerve conduction studies and normal non-enhanced MR imaging of whole spine, but whose subsequent investigations showed delayed somatosensory evoked potential (SSEP) responses of the lower limbs, elevated cerebrospinal fluid (CSF) protein and lumbosacral nerve roots enhancement on MR imaging. We diagnosed CISP and he improved following intravenous immunoglobulin. Proposed diagnostic criteria for CISP are sensory symptoms with a polyneuropathic distribution without weakness, and normal motor and sensory nerve conduction and electromyography (EMG) studies, plus at least two of: abnormal SSEPs not due to central nervous system (CNS) involvement, MRI showing gadolinium enhancement or hypertrophy of the nerve roots, cauda equina or plexuses, and elevated CSF protein with normal cell count. Intravenous immunoglobulin is an effective treatment.
- neuropathy
Statistics from Altmetric.com
Read the full text or download the PDF:
Other content recommended for you
- Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database
- Comparison of the diagnostic accuracy of the 2021 EAN/PNS and 2010 EFNS/PNS diagnostic criteria for chronic inflammatory demyelinating polyradiculoneuropathy
- CIDP presenting as recurrent severe back pain without weakness or sensory loss
- Unclassified clinical presentations of chronic inflammatory demyelinating polyradiculoneuropathy
- A practical approach to enlargement of nerves, plexuses and roots
- Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype
- The dorsal root ganglion under attack: the acquired sensory ganglionopathies
- Clinical assessment of the sensory ataxias; diagnostic algorithm with illustrative cases
- Uniform demyelination and more severe axonal loss distinguish POEMS syndrome from CIDP
- Chronic inflammatory demyelinating polyradiculoneuropathy in solid organ transplant recipients: a prospective study