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Sickle cell disease and fat embolism: a rare complication of vaso-occlusive crisis
  1. Angeliki G Filippatou1,
  2. Muhammad Naveed1,
  3. Daniel P Barry1,
  4. Scott R Deboer2,
  5. Christopher J Haas1
  1. 1Department of Internal Medicine, MedStar Health, Baltimore, Maryland, USA
  2. 2Department of Neurology, MedStar Health, Baltimore, Maryland, USA
  1. Correspondence to Dr Angeliki G Filippatou, Department of Internal Medicine, MedStar Health, Baltimore, MD 21218, USA; afilipp5{at}jhmi.edu

Abstract

A 61-year-old woman was admitted to the hospital for management of a painful vaso-occlusive crisis. She had a history of sickle cell beta-thalassaemia and end-stage renal disease managed with intermittent haemodialysis. While hospitalised, she became lethargic and unresponsive and developed acute chest syndrome. Initial MR scan of brain, cerebrospinal fluid examination and continuous electroencephalogram were unremarkable, but subsequent MR scan of brain identified a right transverse venous sinus thrombosis and extensive supratentorial and infratentorial microhaemorrhages consistent with fat emboli. We; therefore, discuss a case of non-traumatic fat embolism syndrome, a rare complication of sickle cell disease.

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Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information.

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Footnotes

  • Contributors All authors participated in drafting and revision of the manuscript for important intellectual content.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally reviewed by Anthony Pereira, London, UK.

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