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Chronic meningitis, seizures and myoclonus
  1. James Joseph McDonald1,2,
  2. Matthew Jones3,
  3. Colin Smith4,
  4. Peter L Foley1,2,
  5. Liam Lee2,
  6. Richard Davenport1
  1. 1Department of Clinical Neurosciences, NHS Lothian, Edinburgh, UK
  2. 2The University of Edinburgh, Edinburgh, UK
  3. 3Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK
  4. 4Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr James Joseph McDonald, Department of Clinical Neurosciences, NHS Lothian, Edinburgh EH16 4SA, UK; james.mcdonald{at}


A 70-year-old retired male plumber was admitted with reduced consciousness following a recent onset of confusion and headache. He developed encephalopathy, seizures and myoclonus. He died despite treatment 10 weeks later. This article reports the clinicopathological conference presented at the Edinburgh Clinical Neurology Course 2021.

  • CSF
  • MRI
  • neurooncology
  • myoclonus
  • epilepsy

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  • Contributors JJM: initial draft, manuscript revisions and literature review. MJ: case discussant and manuscript revision. CS: provision of pathology images and manuscript revision. PLF: manuscript revision and clinical care of patient. LL: provision of clinical data tables and figures and manuscript revisions. RD: overall concept and manuscript revisions.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed by Michael Halmagyi, Sydney, Australia.

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