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Abstract
A 68-year-old Brazilian woman had 3 months of progressive fatigue, difficulty walking and 18 kg weight loss. On examination, there was gait apraxia and executive dysfunction. MR scan of brain showed communicating hydrocephalus and a cerebrospinal fluid showed 105 white cells/µL (≤5), predominantly lymphocytes, protein of 1.35 g/L (0.15–0.45) and the glucose content of 0.06 mmol/L (3.3–4.4). We suspected an infective cause and used of metagenomic next-generation sequencing to diagnose neurocysticercosis. This case highlights the challenge of diagnosing chronic meningitis and the relevance of genetic approaches in diagnosing neurological infections.
- APRAXIA
- COGNITION
- CSF
- GAIT
- INFECTIOUS DISEASES
Data availability statement
Data are available in a public, open access repository.
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Data availability statement
Data are available in a public, open access repository.
Footnotes
Correction notice This article has been corrected since it was published Online First. An author last name and initials in the contributors section have been updated.
Contributors DAP: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data; GBPF: major role in the acquisition of data; Analysis or interpretation of data; LFdSG: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data; ACF: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data; JRP: major role in the acquisition of data; analysis or interpretation of data; AMD: major role in the acquisition of data; analysis or interpretation of data; RdAG: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data; study concept or design; analysis or interpretation of data.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned. Externally peer reviewed by Hadi Manji, London, UK.
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