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Non-convulsive status epilepticus associated with Whipple’s disease
  1. Eva Diab1,2,
  2. Mickael Aubignat3,
  3. Ruxandra Sarba4,
  4. Sandrine Wannepain3,
  5. Olivier Godefroy3,
  6. Ines Masmoudi3
  1. 1Clinical Neurophysiology, CHU Amiens-Picardie, Amiens, France
  2. 2UR7516 CHIMERE, University of Picardie Jules Verne, Amiens, France
  3. 3Department of Neurology, Amiens University Hospital, Amiens, France
  4. 4Department of Hepato-Gastro-Enterology, CHU Amiens-Picardie, Amiens, France
  1. Correspondence to Dr Eva Diab, Clinical Neurophysiology, CHU Amiens-Picardie, Amiens, Hauts-de-France, France; diab.eva{at}


A 69-year-old woman developed non-convulsive status epilepticus during inpatient investigation for abdominal pain. Initial detailed investigations did not identify the cause of seizures, but a jejunal biopsy and PCR testing in various fluids led to the diagnosis of Whipple’s disease with neurological involvement. The seizures were controlled but she subsequently had moderate cognitive impairment. Whipple’s disease is an important diagnosis, being treatable with antibiotics. Testing for Whipple’s disease is not part of the recommended workup in for status epilepticus, but this case highlights the importance of considering this condition.


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Data availability statement

Data are available in a public, open access repository.

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  • Contributors ED, MA and IM were involved in the design and conception of the paper. ED wrote the first draft. All authors and co-authors edited, critically revised and approved the final manuscript for submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally reviewed by Josemir Sander, London, UK.

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