Article Text
Abstract
Chorea is a hyperkinetic movement disorder characterised by excessive spontaneous movements that are irregularly timed, randomly distributed and abrupt. In this article, the authors discuss the causes of chorea, particularly Huntington’s disease and the genetic syndromes that may resemble it, including HDL1-3, inherited prion disease, spinocerebellar ataxias 1, 3 and 17, neuroacanthocytosis, dentatorubro-pallidoluysian atrophy (DRPLA), brain iron accumulation disorders, Wilson’s disease, benign hereditary chorea, Friedreich’s ataxia and mitochondrial disease. Acquired causes of chorea include vascular disease, post-infective autoimmune central nervous system disorders (PANDAS), drugs, systemic lupus erythematosus, antiphospholipid syndrome, thyrotoxicosis, AIDS, chorea gravidarum, and polycythaemia rubra vera. The authors suggest an approach to the clinical assessment of chorea, the value of investigations, including genetic tests (for which they offer a structured framework highlighting the importance of prior counselling), and finally briefly discuss symptomatic drug treatment of chorea.
Statistics from Altmetric.com
Read the full text or download the PDF:
Other content recommended for you
- The differential diagnosis of Huntington's disease-like syndromes: ‘red flags’ for the clinician
- Huntington’s disease: diagnosis and management
- Autoimmune choreas
- Chorea and related disorders
- Chorea disclosing deterioration of polycythaemia vera
- Huntington’s disease-like 2: a phenocopy not to miss
- Late recurrences of Sydenham’s chorea are not associated with anti-basal ganglia antibodies
- Hydrocephalus induced chorea
- Hydrocephalus induced chorea
- Acute dyskinesia in a patient with schizophrenia