RT Journal Article SR Electronic T1 Neurolupus JF Practical Neurology JO Pract Neurol FD BMJ Publishing Group Ltd SP 4 OP 15 DO 10.1136/jnnp.2009.200071 VO 10 IS 1 A1 Fady G Joseph A1 Neil J Scolding YR 2010 UL http://pn.bmj.com/content/10/1/4.abstract AB Systemic lupus erythematosus (SLE) is not an uncommon condition. Most neurologists are well aware that it can cause a wide range of neurological complications, and SLE almost invariably appears on ‘differential diagnosis’ lists in cases of clinical uncertainty. However, the precise nature of the manifestations of SLE in the central and peripheral nervous systems is perhaps less widely understood, and misperceptions about phenomenology and treatment are common. Here we survey some of the main primary neurological complications of SLE—‘neurolupus’—while acknowledging that secondary problems, either iatrogenic or relating to other consequences of SLE (eg, hypertensive CNS disease, for example, secondary to renal lupus) are neither less serious nor less treatable.