RT Journal Article SR Electronic T1 Questions and Answers About the Neurology of Gluten Sensitivity JF Practical Neurology JO Pract Neurol FD BMJ Publishing Group Ltd SP 354 OP 357 VO 3 IS 6 A1 DSNA Pengiran Tengah A1 AJ Wills YR 2003 UL http://pn.bmj.com/content/3/6/354.abstract AB In recent years there has been a plethora of articles claiming that various neurological syndromes are associated with or are caused by gluten sensitivity. However, the busy clinical neurologist needs to know the answers to just two main questions – does gluten sensitivity predispose patients to the development of various neurological complications, and should a patient with a cryptogenic neurological illness be investigated for occult gluten sensitivity (and if so how)? WHAT IS GLUTEN SENSITIVITY? Coeliac disease is a classic gluten sensitive enteropathy, typically presenting in childhood. It is common with a prevalence of between 1 : 80 and 1 : 300. There is characteristic small bowel villous atrophy (Fig. 1a) associated with abdominal pain, malabsorption and weight loss. A gluten-free diet rapidly reverses this atrophy (within weeks) (Fig. 1b), corrects malabsorption and leads to symptomatic improvement. In addition, patients may sometimes present with non-specific or trivial complaints and the diagnosis