PT  - JOURNAL ARTICLE
AU  - Katherine Murray
TI  - Creutzfeldt–Jacob disease mimics, or how to sort out the subacute encephalopathy patient
AID  - 10.1136/jnnp.2010.235721
DP  - 2011 Feb 01
TA  - Practical Neurology
PG  - 19--28
VI  - 11
IP  - 1
4099  - http://pn.bmj.com/content/11/1/19.short
4100  - http://pn.bmj.com/content/11/1/19.full
SO  - Pract Neurol2011 Feb 01; 11
AB  - Sporadic Creutzfeldt–Jacob disease (CJD) is a rare untreatable neurodegenerative disease which every neurologist will occasionally encounter during their career. However, it is likely to appear on their differential diagnosis list significantly more frequently. Numerous conditions can present with subacute encephalopathy which might be sporadic CJD and this article explores these diagnoses. It includes the commonest sporadic CJD mimics which are neurodegenerative, and highlights the relatively rare treatable mimics which must not be missed. It discusses relevant investigations, including serum antibodies, CSF, electroencephalography and MR brain imaging, and strategies when preliminary investigations fail to support sporadic CJD but no alternative diagnosis is readily apparent.