PT - JOURNAL ARTICLE AU - Claire M Rice TI - Disease modification in multiple sclerosis: an update AID - 10.1136/practneurol-2013-000601 DP - 2014 Feb 01 TA - Practical Neurology PG - 6--13 VI - 14 IP - 1 4099 - http://pn.bmj.com/content/14/1/6.short 4100 - http://pn.bmj.com/content/14/1/6.full SO - Pract Neurol2014 Feb 01; 14 AB - Although there has been unequivocal progress in the development of treatments for multiple sclerosis over the last 20 years, currently licensed treatments have demonstrated convincing effects on disease course only with reference to relapse frequency. This review summarises the progress made, highlights the indications for, and limitations of, current disease-modifying therapies and discusses some interventions currently in development.