PT - JOURNAL ARTICLE AU - Ahmad, Omar AU - Rowe, Dominic Brock TI - Adult-onset Alexander's disease mimicking degenerative disease AID - 10.1136/practneurol-2015-001144 DP - 2015 Oct 01 TA - Practical Neurology PG - 393--395 VI - 15 IP - 5 4099 - http://pn.bmj.com/content/15/5/393.short 4100 - http://pn.bmj.com/content/15/5/393.full SO - Pract Neurol2015 Oct 01; 15 AB - Adult-onset Alexander's disease is a rare leukodystrophy that can present later in life in a variety of ways, often mimicking more common neurodegenerative conditions. We present two cases with novel mutations, diagnosed from their characteristic MR scan findings. Even in much older people, clinicians should have a high clinical suspicion if there are typical imaging findings.