RT Journal Article
SR Electronic
T1 Hiding in plain sight: a closer look at posterior cortical atrophy
JF Practical Neurology
JO Pract Neurol
FD BMJ Publishing Group Ltd
SP 5
OP 13
DO 10.1136/practneurol-2014-000883
VO 15
IS 1
A1 Shin C Beh
A1 Brinda Muthusamy
A1 Peter Calabresi
A1 John Hart
A1 David Zee
A1 Vivek Patel
A1 Elliot Frohman
YR 2015
UL http://pn.bmj.com/content/15/1/5.abstract
AB Posterior cortical atrophy (PCA) is a neurodegenerative syndrome dominated by deterioration of higher visual function (particularly visuospatial and visuoperceptual abilities). It is most commonly due to Alzheimer's disease pathology, but may also be caused by dementia with Lewy bodies, corticobasal degeneration or Creutzfeldt-Jakob disease. Patients often present to optometrists, ophthalmologists and/or neurologists with non-specific visual complaints, and unless clinicians seek the specific symptoms and signs of PCA (beyond that of the ‘standard’ neurological examination), this infrequent disorder is easily missed, delaying its diagnosis and treatment. We review the clinical features of PCA, focusing on its visual manifestations, to help neurologists recognise this important syndrome.