PT  - JOURNAL ARTICLE
AU  - Ali Kirresh
AU  - Alex Everitt
AU  - Onn Min Kon
AU  - Ranan DasGupta
AU  - Matthew C Pickering
AU  - Helen J Lachmann
TI  - Trapped without a diagnosis: Tumour necrosis factor receptor-associated periodic syndrome (TRAPS)
AID  - 10.1136/practneurol-2015-001342
DP  - 2016 Aug 01
TA  - Practical Neurology
PG  - 304--307
VI  - 16
IP  - 4
4099  - http://pn.bmj.com/content/16/4/304.short
4100  - http://pn.bmj.com/content/16/4/304.full
SO  - Pract Neurol2016 Aug 01; 16
AB  - Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant condition caused by mutations in the TNFRSF1A gene. It is characterised by recurrent episodes of myalgia, followed by prolonged fever, migratory rashes, headache, serositis, arthralgia, abdominal pain and periorbital oedema. We describe a 49-year-old man with a self-limiting episode of paraparesis who reported recurrent bouts of abdominal symptoms and headaches since childhood. He had a persistent inflammatory response with night sweats and weight loss. We diagnosed TRAPS 2 years after having identified a TNFRSF1A gene mutation. His symptoms and inflammatory response resolved dramatically with the interleukin-1 receptor antagonist anakinra.