PT - JOURNAL ARTICLE AU - Sarah Miller AU - Alex J Sinclair AU - Brendan Davies AU - Manjit Matharu TI - Neurostimulation in the treatment of primary headaches AID - 10.1136/practneurol-2015-001298 DP - 2016 Oct 01 TA - Practical Neurology PG - 362--375 VI - 16 IP - 5 4099 - http://pn.bmj.com/content/16/5/362.short 4100 - http://pn.bmj.com/content/16/5/362.full SO - Pract Neurol2016 Oct 01; 16 AB - There is increasing interest in using neurostimulation to treat headache disorders. There are now several non-invasive and invasive stimulation devices available with some open-label series and small controlled trial studies that support their use. Non-invasive stimulation options include supraorbital stimulation (Cefaly), vagus nerve stimulation (gammaCore) and single-pulse transcranial magnetic stimulation (SpringTMS). Invasive procedures include occipital nerve stimulation, sphenopalatine ganglion stimulation and ventral tegmental area deep brain stimulation. These stimulation devices may find a place in the treatment pathway of headache disorders. Here, we explore the basic principles of neurostimulation for headache and overview the available methods of neurostimulation.