PT - JOURNAL ARTICLE AU - Cope, Thomas E AU - Breen, David P AU - Chawda, Sanjiv AU - Cifelli, Alberto TI - Anti-collapsin response mediator protein 5 encephalitis masquerading as a low-grade brain tumour AID - 10.1136/practneurol-2016-001379 DP - 2016 Oct 01 TA - Practical Neurology PG - 376--380 VI - 16 IP - 5 4099 - http://pn.bmj.com/content/16/5/376.short 4100 - http://pn.bmj.com/content/16/5/376.full SO - Pract Neurol2016 Oct 01; 16 AB - A 71-year-old woman presented acutely with seizures; her MRI suggested a low-grade glioma of the right temporal lobe. Over the preceding 18 months, she had developed progressive limb chorea and orofacial dyskinesia. Examination showed a predominantly amnestic cognitive profile. Initial investigations were normal, but later she was found to have antibodies to collapsin response mediator protein 5 (also called CV2). Her symptoms and neuroimaging abnormalities gradually improved without treatment. Four months later, surveillance imaging with 18F-fluorodeoxyglucose-positron-emission tomography revealed a lesion confirmed by biopsy as a TX, N2, M0 small-cell lung cancer. This case is unusual for the strikingly unilateral neuroimaging abnormalities, which led to an initial misdiagnosis, and the spontaneous symptomatic improvement without treatment. In retrospect, the co-occurrence of paraneoplastic chorea, limbic encephalitis and neuropathy in the presence of an occult lung tumour make this almost a ‘full house’ of symptoms associated with antibodies to collapsin response mediator protein 5. It underlines the importance in clinical reasoning of avoiding the cognitive errors of premature closure and anchoring.