TY - JOUR T1 - Highlights from this issue JF - Practical Neurology JO - Pract Neurol SP - 425 LP - 425 DO - 10.1136/practneurol-2016-001550 VL - 16 IS - 6 AU - Phil E M Smith AU - Geraint N Fuller Y1 - 2016/12/01 UR - http://pn.bmj.com/content/16/6/425.abstract N2 - Neurology is a diagnostic specialty. While it is true that neurologists are spending more time managing neurological disorders than they ever did—in light of the range and complexity of treatments available—the management and prognosis still all stem from the diagnosis.However, not all diagnoses are equal and we have several cases that illustrate this. Richard Ibitoye and colleagues (see page 496) describe a patient with epilepsy and ovarian failure (clinical diagnosis) who also had a leukodystrophy (radiological diagnosis), in turn related to a mutation in EIF2B5 gene (genetic diagnosis). Matthew Evans and colleagues explore a patient with the ‘16 syndrome’, an educational anatomical diagnosis (see page 484); Mihaela Boca and colleagues (see page 458) discuss diagnosis that evolved from clinical to radiological to pathological and aetiological, in a … ER -