RT Journal Article SR Electronic T1 Asterixis JF Practical Neurology JO Pract Neurol FD BMJ Publishing Group Ltd SP 60 OP 62 DO 10.1136/practneurol-2016-001393 VO 17 IS 1 A1 Ellul, Mark A A1 Cross, Timothy J A1 Larner, Andrew J YR 2017 UL http://pn.bmj.com/content/17/1/60.abstract AB Adams and Foley described asterixis in the 1940s in patients with hepatic encephalopathy, but it has since been associated with a wide range of potential causes, both in neurology and general medicine. Here, we review the history, characteristics and clinical significance of this important clinical sign.