PT - JOURNAL ARTICLE AU - Caroline Hayhurst TI - Contemporary management of low-­grade glioma: a paradigm shift in neuro-oncology AID - 10.1136/practneurol-2017-001604 DP - 2017 Jun 01 TA - Practical Neurology PG - 183--190 VI - 17 IP - 3 4099 - http://pn.bmj.com/content/17/3/183.short 4100 - http://pn.bmj.com/content/17/3/183.full SO - Pract Neurol2017 Jun 01; 17 AB - Supratentorial diffuse intrinsic low-grade gliomas represent a distinct but heterogenous group of tumours, with the propensity to grow and to differentiate into malignant tumours. They have been historically viewed in the ‘benign’ spectrum of intrinsic brain tumours, so a watch-and-wait policy was often adopted. With recent advances in our understanding of the natural history of these tumours, combined with advances in surgical technique, an aggressive approach is now recommended. Increasing quality evidence of the impact of tumour resection and multicentre trials of adjuvant radiotherapy and chemotherapy have led to a new algorithm for low-grade glioma management. This review aims to outline the emerging evidence that has shifted neuro-oncology practice.